Automated seizure detection is of great importance to epilepsy diagnosis and treatment.

The low-resource label analysis and representation visualization further illustrate the effectiveness of our pre-training strategy.

Emergent phenomena -- onset of epileptic seizures, sudden customer churn, or pandemic outbreaks -- often arise from hidden causal interactions in complex systems. We propose a machine learning method for their early detection that addresses a core challenge: unveiling and harnessing a system's latent causal structure despite the data-generating process being unknown and partially observed. The method learns an optimal feature representation from a one-parameter family of estimators -- powers of the empirical covariance or precision matrix -- offering a principled way to tune in to the underlying structure driving the emergence of critical events. A supervised learning module then classifies the learned representation. We prove structural consistency of the family and demonstrate the empirical soundness of our approach on seizure detection and churn prediction, attaining competitive results in both. Beyond prediction, and toward explainability, we ascertain that the optimal covariance power exhibits evidence of good identifiability while capturing structural signatures, thus reconciling predictive performance with interpretable statistical structure.

Automated seizure detection (ASD) using intracranial electroencephalography (iEEG) is critical for effective epilepsy treatment. However, the significant domain shift of iEEG signals across subjects poses a major challenge, limiting their applicability in real-world clinical scenarios. In this paper, we address this issue by analyzing the primary cause behind the failure of existing iEEG models for subject-independent seizure detection, and identify a critical universal seizure pattern: seizure events consistently exhibit higher average amplitude compared to adjacent normal events. To mitigate the domain shifts and preserve the universal seizure patterns, we propose a novel self-comparison mechanism.

Sudden Unexpected Death in Epilepsy (SUDEP) and acute ischemic stroke are life-threatening conditions involving complex interactions across cortical, brainstem, and autonomic systems. We present a unified geometric-stochastic multimodal deep learning framework that integrates EEG, ECG, respiration, SpO2, EMG, and fMRI signals to model SUDEP and stroke vulnerability. The approach combines Riemannian manifold embeddings, Lie-group invariant feature representations, fractional stochastic dynamics, Hamiltonian energy-flow modeling, and cross-modal attention mechanisms. Stroke propagation is modeled using fractional epidemic diffusion over structural brain graphs. Experiments on the MULTI-CLARID dataset demonstrate improved predictive accuracy and interpretable biomarkers derived from manifold curvature, fractional memory indices, attention entropy, and diffusion centrality. The proposed framework provides a mathematically principled foundation for early detection, risk stratification, and interpretable multimodal modeling in neural-autonomic disorders.

Transfer learning aims to optimize performance in a target task by learning from a related source problem. In this work, we propose an efficient transfer learning method using a tensor kernel machine. Our method takes inspiration from the adaptive SVM and hence transfers 'knowledge' from the source to the 'adapted' model via regularization. The main advantage of using tensor kernel machines is that they leverage low-rank tensor networks to learn a compact non-linear model in the primal domain. This allows for a more efficient adaptation without adding more parameters to the model. To demonstrate the effectiveness of our approach, we apply the adaptive tensor kernel machine (Adapt-TKM) to seizure detection on behind-the-ear EEG. By personalizing patient-independent models with a small amount of patient-specific data, the patient-adapted model (which utilizes the Adapt-TKM), achieves better performance compared to the patient-independent and fully patient-specific models. Notably, it is able to do so while requiring around 100 times fewer parameters than the adaptive SVM model, leading to a correspondingly faster inference speed. This makes the Adapt-TKM especially useful for resource-constrained wearable devices.

Complex spatial connectivity patterns, such as interictal suppression and ictal propagation, complicate accurate drug-resistant epilepsy (DRE) seizure detection using stereotactic electroencephalography (SEEG) and traditional machine learning methods. Two critical challenges remain:(1)a low signal-to-noise ratio in functional connectivity estimates, making it difficult to learn seizure-related interactions; and (2)expert labels for spatial pathological connectivity patterns are difficult to obtain, meanwhile lacking the patterns' representation to improve seizure detection. To address these issues, we propose a novel node-graph dual contrastive learning framework, Seizure-NGCLNet, to learn SEEG interictal suppression and ictal propagation patterns for detecting DRE seizures with high precision. First, an adaptive graph augmentation strategy guided by centrality metrics is developed to generate seizure-related brain networks. Second, a dual-contrastive learning approach is integrated, combining global graph-level contrast with local node-graph contrast, to encode both spatial structural and semantic epileptogenic features. Third, the pretrained embeddings are fine-tuned via a top-k localized graph attention network to perform the final classification. Extensive experiments on a large-scale public SEEG dataset from 33 DRE patients demonstrate that Seizure-NGCLNet achieves state-of-the-art performance, with an average accuracy of 95.93%, sensitivity of 96.25%, and specificity of 94.12%. Visualizations confirm that the learned embeddings clearly separate ictal from interictal states, reflecting suppression and propagation patterns that correspond to the clinical mechanisms. These results highlight Seizure-NGCLNet's ability to learn interpretable spatial pathological patterns, enhancing both seizure detection and seizure onset zone localization.

Automated seizure detection (ASD) using intracranial electroencephalography (iEEG) is critical for effective epilepsy treatment.

Access to clinical multi-channel EEG remains limited in many regions worldwide. We present NEUROSKY-EPI, the first open dataset of single-channel, consumer-grade EEG for epilepsy, collected in a South Asian clinical setting along with rich contextual metadata. To explore its utility, we introduce EmbedCluster, a patient-stratification pipeline that transfers representations from EEGNet models trained on clinical data and enriches them with contextual autoencoder embeddings, followed by unsupervised clustering of patients based on EEG patterns. Results show that low-cost, single-channel data can support meaningful stratification. Beyond algorithmic performance, we emphasize human-centered concerns such as deployability in resource-constrained environments, interpretability for non-specialists, and safeguards for privacy, inclusivity, and bias. By releasing the dataset and code, we aim to catalyze interdisciplinary research across health technology, human-computer interaction, and machine learning, advancing the goal of affordable and actionable EEG-based epilepsy care.

In recent years, machine learning has become an increasingly powerful tool for supporting seizure detection and monitoring in epilepsy care. Traditional approaches focus on identifying seizures only after they begin, which limits the opportunity for early intervention and proactive treatment. In this study, we propose a novel approach that integrates both real-time seizure detection and prediction, aiming to capture subtle temporal patterns in EEG data that may indicate an upcoming seizure. Our approach was evaluated using the CHB-MIT Scalp EEG Database, which includes 969 hours of recordings and 173 seizures collected from 23 pediatric and young adult patients with drug-resistant epilepsy. To support seizure detection, we implemented a range of supervised machine learning algorithms, including K-Nearest Neighbors, Logistic Regression, Random Forest, and Support Vector Machine. The Logistic Regression achieved 90.9% detection accuracy with 89.6% recall, demonstrating balanced performance suitable for clinical screening. Random Forest and Support Vector Machine models achieved higher accuracy (94.0%) but with 0% recall, failing to detect any seizures, illustrating that accuracy alone is insufficient for evaluating medical ML models with class imbalance. For seizure prediction, we employed Long Short-Term Memory (LSTM) networks, which use deep learning to model temporal dependencies in EEG data. The LSTM model achieved 89.26% prediction accuracy. These results highlight the potential of developing accessible, real-time monitoring tools that not only detect seizures as traditionally done, but also predict them before they occur. This ability to predict seizures marks a significant shift from reactive seizure management to a more proactive approach, allowing patients to anticipate seizures and take precautionary measures to reduce the risk of injury or other complications.